MD HQ limits the size of file uploads to 16MB.  Generally speaking, this is plenty for any normal document, even documents that are hundreds of pages long. However, PDFs in particular can sometimes be much larger, depending on the compression settings of the file. A well-optimized PDF can be thousands of pages long and fit within the 16MB limit, whereas a very poorly optimized single-page PDF can be enormous. 

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Tips for optimizing file size:

(1) Set your scanner resolution to150 DPI or lower

Generally 96 DPI is sufficient to generate a highly readable document, so if it's a particularly long document you may want to reduce your settings to 96.

(2) Turn on OCR (Optical character recognition)

If OCR (Optical Character Recognition = text recognition in scanned documents) is available, it can dramatically reduce the file-size. Plus it has the added bonus of allowing you to copy text from the resulting scan. Some scanner settings will refer to this as "Text Enhancement".

(3) Optimize Received PDFs using Adobe Acrobat

If someone sent the PDF to you (it's not something you're scanning in) and you need to reduce the file size, you can open it in Adobe Acrobat (standard or Pro) and do the following to optimize the file size:

Keywords: smaller file, document too big